Medication Compliance Tends to Reduce All Death, Suicide, and Hospitalization: In a study of adults with a diagnosis of schizophrenia who filled at least 1 prescription for risperidone, olanzapine, or quetiapine in Quebec and Saskatchewan over 4 years, 41,754 and 3291 patients, poor compliance was seen in 23% of patients from Quebec and 34% of those from Saskatchewan. Good compliance was associated with a 30% decreased risk of all-cause hospitalization and 60% decrease in psychosis-related hospitalization. The Quebec data also a 42% decreased risk of death with good compliance (adjusted HR = 0.58) and 32% decrease in suicide (adjusted HR = 0.68) that was not observed in Saskatchewan. Compliance with refilling prescriptions for atypical antipsychotic agents and its association with the risks for hospitalization, suicide, and death in patients with schizophrenia in Quebec and Saskatchewan: a retrospective database study. Ward A, et al. Concord, Massachusetts. . Clin Ther 2006 Nov;28(11):1912-21.

Haldol, Olanzapine Cause Brain Shrinkage in Monkeys: Three groups of six macaque monkeys each were exposed to oral haloperidol, olanzapine or sham for a 17-27 month period. There was an 8-11% reduction in mean fresh brain weights as well as left cerebrum fresh weights and volumes in both drug-treated groups compared to sham. The differences were observed across all major brain regions (frontal, parietal, temporal, occipital, and cerebellum), but was increased in the frontal and parietal regions in both gray and white matter. There was a general shrinkage effect of approximately 20% and a highly significant variation in shrinkage across brain regions. The Influence of Chronic Exposure to Antipsychotic Medications on Brain Size before and after Tissue Fixation: A Comparison of Haloperidol and Olanzapine in Macaque Monkeys. Dorph-Petersen KA, Pierri JN, et al. University of Pittsburgh. Neuropsychopharmacology 9 March 2005

Hip Fractures Increased by Prolactin-Raising Antipsychotics: There is an association between decreased bone mineral density, schizophrenia, and prolactin-raising antipsychotic medication. In a case control study of over 16,000 hip fractures and 23,000 controls, in the multivariate analysis, prolactin-raising antipsychotics were independently associated with hip fracture but schizophrenia was not: OR=2.12 for men, OR=1.93 for women. Risk of hip fracture in patients with a history of schizophrenia. Howard L, et al.  De Crespigny Park, London, UK. . Br J Psychiatry 2007 Feb;190:129-34.