Oct 2004 #4
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Americans: Vitamin D Deficiency Very Common; Even Worse Over Age 50: The government recommends dietary and supplemental vitamin D of 200 IU per day for people under 50, 400 IU per day for ages 51 to 70, and 600 IU per day over 70. The diets of 27,000 people in the Third National Health and Nutrition Examination Survey and 19,000 people in the Continuing Survey of Food Intakes by Individuals found that less than 10% of adults 50 to 70 years old, and only about 2% of people over 70, were found to be getting the recommended amounts of vitamin D from food and only 30% of people ages 50-70 and 10% of those over 70 when counting supplements as well. Among people 14 to 50 years old, 50% of females and 65% of males were getting recommended amounts vs. 53 -63% of all children. A previous study found 42% of hospitalized patients under age 65 were vitamin D deficient, and 37% of people eating recommended amounts of vitamin D were still deficient. J Amer Dietetic Assn 2004;104:980–3. For more, see Vitamin D.

Yogurt Suppresses Ulcer-Causing H. Pylori: Evidence suggests that ingesting lactic acid bacteria exerts a suppressive effect on Helicobacter pylori infection in both animals and humans. Supplementing with Lactobacillus- and Bifidobacterium-containing yogurt (AB-yogurt) was shown to improve the rates of eradication of H. pylori in humans. 59 adult volunteers infected with H. pylori were given AB-yogurt twice daily after a meal for 6 wk. Eleven were treated with milk placebo. Bifidobacterium exerted an in vitro inhibitory effect against H. pylori, whereas Lactobacillus did not. AB-yogurt decreased the urease activity of H. pylori, i.e., suppressed H. pylori, after 6 wk of therapy (P < 0.0001). Effects of ingesting Lactobacillus- and Bifidobacterium-containing yogurt in subjects with colonized Helicobacter pylori. Wang KY, Li SN, Liu CS, Perng DS, Su YC, Wu DC, Jan CM, Lai CH, Wang TN, Wang WM. Taiwan. Am J Clin Nutr. 2004 Sep;80(3):737-41. For more, see Yogurt.

Increased BP Linked to Hippocampal Atrophy: The hippocampus is vulnerable to global ischemia, which may lead to atrophy. In a sample of Japanese-American men with 30 year follow-up with brain MRIs, adjusting for sociodemographic factors, other cardiovascular risk factors, apolipoprotein E allele, and correlated brain pathology, those never treated with antihypertensive medication had a significantly increased risk for hippocampal atrophy of 70% (OR 1.7). For high systolic BP it was OR=1.98 and for high diastolic BP (>90 mmHg) OR=3.51. Midlife blood pressure and the risk of hippocampal atrophy: the Honolulu Asia Aging Study. Korf ES, White LR, Scheltens P, Launer LJ. Universiteit Medical Center, Amsterdam. Hypertension. 2004 Jul;44(1):29-34

Reduced Blood Flow Linked to Dementia: In 27 adults with Alzheimer's disease (AD), seven with frontotemporal dementia (FTD), six with vascular dementia (VaD), and 12 normal controls, a close coupling was evident between reduced regional cerebral blood flow and dementia. Relationship between cognitive function and regional cerebral blood flow in different types of dementia. Osawa A, Maeshima S, Shimamoto Y, Maeshima E, Sekiguchi E, Kakishita K, Ozaki F, Moriwaki H. Kawasaki Medical School, Japan. Disabil Rehabil. 2004 Jun 17;26(12):739-45.

Memantine Helped Keep Alzheimer's Autonomous: In a 28-week DB PC study of 252 adults with moderately-severe to severe AD, memantine-treated patients were three times more likely [OR = 3.03;] to remain autonomous. Memantine enhances autonomy in moderate to severe Alzheimer's disease. Rive B, Vercelletto M, Damier FD, Cochran J, Francois C. Paris, France. Int J Geriatr Psychiatry. 2004 May;19(5):458-64. Ed: Memantine is awfully expensive. While perhaps effective, because the benefit is quite small, it does not appear cost-effective. Most people would choose to spend their money otherwise if it were their own money, which in a way it is.

Atypicals Not Found to Increase Diabetes: In a retrospective study of outpatients receiving atypical antipsychotics (n = 10,265) compared to those on traditional antipsychotics (n = 4,607), antidepressants (n = 60,856) or antibiotics (n = 59,878), the annual unadjusted new cases of diabetes per 1000 per year were 7.5 for atypical antipsychotics, 11.3 for traditional antipsychotics, 7.8 for antidepressants and 5.1 for antibiotics. In multivariable analyses, age, male sex and Chronic Disease Score were associated with greater odds of diabetes onset. Multivariable analysis showed increased odds of diabetes for clozapine, olanzapine, ziprasidone and thioridazine (relative to risperidone), but these comparisons did not reach statistical significance. Atypical antipsychotic drugs and diabetes mellitus in a large outpatient population: a retrospective cohort study. Ostbye T, Curtis LH, Masselink LE, Hutchison S, Wright A, Dans PE, Schulman KA, Krishnan RR. Duke University. Pharmacoepidemiol Drug Saf. 2004 Sep 16. Ed: This new study is certainly at odds with the new FDA requirement that patients be warned about increased risk of diabetes with atypical anti-psychotics.

Mitochondrial Gene Defect Associated with Some Bipolar Disease: In a study of 104 parents and children of NIMH pedigrees and of Japanese patients, polymorphisms in the promoter region of NDUFV2 are a genetic risk factor for bipolar disorder by affecting promoter activity. NDUFV2 at 18p11 encodes a subunit of the complex I, reduced nicotinamide adenine dinucleotide (NADH) ubiquinone oxidoreductase. Association of mitochondrial complex I subunit gene NDUFV2 at 18p11 with bipolar disorder in Japanese and the National Institute of Mental Health pedigrees. Washizuka S, Iwamoto K, et al. Saitama, Japan. Biol Psychiatry. 2004 Oct 1;56(7):483-9

Walking May Lower Dementia Risk: In a 5-year follow-up study of 2257 physically capable men ages 71-93 years in the Honolulu-Asia Aging Study, 158 cases of dementia were identified (15.6/1000 person-years). After adjusting for age, men who walked the least (<0.25 mile/d) experienced a 77% excess risk of dementia compared with those who walked more than 2 mile/d (17.8 vs. 10.3/1000 person-years. These associations persisted after accounting for other factors, including the possibility that limited amounts of walking could be the result of a decline in physical function due to preclinical dementia. Walking and dementia in physically capable elderly men. Abbott RD, White LR, Ross GW, Masaki KH, Curb JD, Petrovitch H. University of Virginia JAMA. 2004 Sep 22;292(12):1447-53. For more, see Dementia and Exercise.

Fibroblast Growth Factor 1 Gene Polymorphism Increases Risk of AD: Fibroblast growth factor 1 (FGF1) protects selective neuronal populations against neurotoxic effects such as those in Alzheimer's disease (AD) and HIV encephalitis. In a study of 100 Japanese autopsy-confirmed late-onset AD patients and 106 age-matched non-demented controls, researchers examined the FGF1 and apolipoprotein E (APOE) genes. The promoter polymorphism (-1385 A/G) was significantly associated with AD risk. The odds ratio for AD associated with the GG vs non-GG genotype was 2.02, while that of s4 vs non-е┌4 in APOE4 gene was 5.19. The odds ratio for APOEP4 and FGF1 GG carriers was 20.5. Promoter polymorphism in fibroblast growth factor 1 gene increases risk of definite Alzheimer's disease. Yamagata H, Chen Y, Akatsu H, Kamino K, Ito J, Yokoyama S, Yamamoto T, Kosaka K, Miki T, Kondo I. Ehime University, Japan. Biochem Biophys Res Commun. 2004 Aug 20;321(2):320-3. For more, see the Genetics of Alzheimer's.