Meat Might Increase Pancreatic CA: Diet causes up to 80% CA colon, breast, and prostate. Mammal meat, processed meat, and fried meat probably increases colorectal and breast CA and possibly increase lung prostate and pancreatic cancers, while fruits, veggies, Vit E and C probably help decrease several cancers. J Cummings, Cambridge, BMJ 12/12/98 317:1636-4

Pancreatic Cancer May Be Increased by Coffee, Not Tea: 8yr f/u 34000 Iowa women found over 20 pack/yr RR 1.96, trend increase with alcoholwith a trend towards increase with coffee over 17 cups per week vs. <7 cup/w. Harnack, Cancer Epid Biomarkers Prev 12/97;6:1081

NSAID Lowers Rate: Several studies have now found that aspirin and NSAIDs lower the rate of pancreatic cancer. The largest found a 43% decrease with aspirin. U Minn, J Natl Cancer Inst 8/7/02

High Starch Diet in Obese Sedentary Women Incr Panc CA: Harvd, J Natl Cancer Inst 9/4/02 89,000 Nurses Health Study found excess insulin can promote cancer CA. Insulin stimulates panc CA cells and AODM insulin resistant causing more insulin production. Diet of potatoes, rice, and white bread and even fructose faulted as having high glycemic indexes and increasing panc CA 150% in obese sedentary. However, high glycemic foods did not incr panc CA in lean and fit women. 30,000 die annually fr panc CA.

Prophylactic Retinoic Acid May Prevent: Retinoid receptors loaded with retinoic acid oppose tumour promoting and skin-ageing properties of transcription-factor activator-protein 1, which is elevated by UV light. Topical retinoic acid may prove a valuable antidote but needs research altho researcher uses it himself. Lancet ’99;353:1161.

Wrinkles Protective: Smooth faces higher risk than those with wrinkles for developing basal call CA with heavy wrinklers having 90% less risk. Arch Derm 6/14/01

70% Melanoma Due to Single Mutation: Of 2200 odd letters that encode the BRAF protein, one accounted for 80% of all the mutations. The T to A switch in BRAF is also found in ABL, a gene found in myeloid leukaemia. This has been successfully treated with the new generation of tyrosine kinase inhibitors, such as imatinib (Glivec). BMJ 6/15/02; BRAF encodes protein that participates in a cascade of cell-growth signals that are frequently perturbed in CA. The mutations continuously prod cells with a growth signal. Nature 6/27/02.

Vegetables, Beans, Fruit Good: Stomach Cancer Less with Allium Vegetables: High consumption of raw vegetables, fruit, tomatoes, kidney beans and soybean products associated with lower rates. People who consumed garlic en masse 3 times or more per week were 82% of men and 75% of women in the Low Risk Areas, and 1% of men and women in the HRA. J Epidemiol 1999 Nov;9(5):297-305

Spinach, Tofu Help Stomach CA: Stomach cancer Korea’s most prevalent cancer. case-control study increased risk from broiled meats and fishes, salted side dishes (salted/fermented fish products) and salty stewed foods, such as soybean paste thickened stew. Frequent consumption of mung bean pancake, tofu, cabbage, spinach and sesame oil decreased the risk. For meat and fish, pan frying was associated with decreased risk, whereas stewing or broiling was associated with increased risk. Pickled vegetables increased the risk, whereas fresh vegetables did not. In a recent cohort study in Seoul, green vegetables and soybean foods were associated with a decreased risk of stomach cancer. Case-control and cohort studies have reported that ginseng intake decreased the risk of gastric cancer. Int J Cancer 1997;Suppl 10:7-9

Ginseng Associated with Decreased Stomach Cancer: Case control and cohort studies show ginseng decreased risk. Also recent case control study shows broiling or stewing meat increased risk but not pan frying. Salted fish, salty soybean paste stews, increased while tofu, cabbage, spinach, sesame oil decreased risk. Stomach CA most prevalent CA in Korea. Pickled vegetables increased risk. Int J Cancer ’97;Suppl 10:7

Plants, Vitamin C Supplement Good; Animal Protein, Obesity Bad: In a study of 1,095 people with stomach or esophageal cancer to that of 687 healthy controls, regular use of vitamin C supplements was associated with a 40% reduction in the risk of cancer in the middle and lower parts of the stomach. The rate of a specific type of esophageal and stomach cancer, known as adenocarcinoma of the esophagus and gastric cardia, has increased by 300% since the mid-1970s. Plant fiber, dietary beta-carotene, folic acid, vitamin C and vitamin B6 were associated with lower risk of these kinds of cancers, while diets high in cholesterol, and animal protein was linked to higher risk. Obesity was also strongly linked to an increase in these cancers. Susan Mayne, Yale. Cancer Epidemiology, Biomarkers & Prevention 10/01