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Dopamine Transporter Gene Variant Higher in Alcoholics: In 102 healthy adults and 216 alcoholics, the frequency of the allele A9 was significantly higher (P = 0.01) in the group of alcoholics. There was no significant association of the allele A9 with severe withdrawal symptoms or the daily amount of alcohol consumed. Association of the dopamine transporter gene with alcoholism. Kohnke MD, et al. Tubingen, Germany. michael.koehnke@med.uni-tuebingen.de. Alcohol Alcohol. 2005 Sep-Oct;40(5):339-42. Dopamine Transporter Gene Variant Increases Risk of
Delirium, Withdrawal Seizures, Hallucinations: Previous studies have
found an association between the A9 allele (nine-copy repeat) of the dopamine
transporter (DAT) gene and two complications of alcohol withdrawal, namely
delirium tremens (DT) and alcohol withdrawal seizures (AWS). In a study of 64
French alcoholic women, women carrying the A9 allele had more visual
hallucinations during withdrawal than those without this allele (P = 0.03).
However, women with the A9 allele were not more susceptible to DT or AWS than
those without (P = 0.48 and P = 1.00, respectively). The A9 allele of the
dopamine transporter gene increases the risk of visual hallucinations during
alcohol withdrawal in alcohol-dependent women. Limosin F, et al. Creteil,
France. frederic.limosin@ach.ap-hop-paris.fr.
Neurosci Lett. 2004 May 20;362(2):91-4. |